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New scientific pathway discovered that slows memory loss from Alzheimer's

2026-02-10 07:21:00, Shëndeti CNA

New scientific pathway discovered that slows memory loss from Alzheimer's

Scientists have identified a new pathway that could help slow memory loss in people with Alzheimer's disease, a neurodegenerative condition that gradually impairs memory and thinking ability.

The study was conducted by Cold Spring Harbor Laboratory in New York, where researchers found that the enzyme PTP1B plays a role in worsening memory loss in mice with Alzheimer's.

Scientists observed that this enzyme appears to inhibit the normal function of brain immune cells (called microglia) to clear amyloid-beta plaques, protein structures associated with worsening of the disease.

When PTP1B activity is reduced, microglia function better and more effectively remove these toxic plaques from the brain.

According to the study authors, PTP1B interacts with the protein SYK, which helps signal microglia to respond to damage.

By inhibiting PTP1B, microglia can better carry out their "cleaning" functions, which often lose effectiveness as the disease progresses.

Scientists are working on PTP1B inhibitors, molecules that can block the activity of this enzyme. The idea is that these inhibitors could be used in combination with existing drugs, such as donepezil and memantine, to slow the progression of the disease and improve the quality of life for patients.

Currently, treatments used target symptoms, but this new approach raises hope for a more direct effect on the mechanisms that cause memory loss.

Alzheimer's disease is the most common form of dementia and affects tens of millions of people worldwide. According to the World Health Organization, about 55 million people live with dementia, and Alzheimer's accounts for approximately 70% of cases. /CNA 





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