Transplantation of pig kidneys into humans / Scientists take the big step

Pig-to-human kidney transplants are a step closer after monkeys survived for up to two years with organs modified in a laboratory by scientists.

Rejection by the immune system is the main obstacle to giving patients organs grown in laboratory animals.

But research suggests that knocking out certain genes can reduce this risk and increase the chances of success.

The American company eGenesis changed the DNA of pigs to 'turn off ' the highest risk genes and transplanted their kidneys into 21 monkeys, writes The Sun.

On average they survived for three weeks, but one of the monkeys lived up to 758 days, while two were still alive at the end of the study after living more than a year.

eGenesis CEO Dr Michael Curtis said this is a critical step towards successful human clinical trials.

Around 7,000 people in England are on the transplant waiting list and more than 400 die waiting each year.

The scientists said medication to suppress the recipient's immune system is still needed despite the gene modifications.

They hope pigs will be a good source of organs for human patients because they have similar anatomy and grow quickly.

Experiments are also trying to transplant pig hearts into people with heart disease./ CNA

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